Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of osteoarthritis. However, there is limited evidence that they actually improve the underlying pathology of the condition. Moreover, adverse effects are common, limiting their long-term use.
Glucosamine is an intermediate substrate used in the synthesis of glycosaminoglycans and proteoglycans by articular cartilage. Glucosamine is classified as a slow-acting drug in osteoarthritis and stands out as the most efficacious chondroprotective agent currently available. The nutrient has also demonstrated mild anti-inflammatory activity.
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