BioCeuticals Article

Biofilms: what they are and how we can break them down

Biofilms: what they are and how we can break them down
Date: 2017-08-10
Author: Claire Georgiou
Access: Public

What is a biofilm?
Biofilms are formations that occur when a group of microorganisms such as bacteria, fungi, parasites and viruses attach themselves to a surface and create a colony.1 The biofilm forms itself into a type of ‘shield’ that has a glue-like consistency, often referred to as ‘slime’.1 These biofilms act as a barrier and help the colony to defend itself against antimicrobial treatments and our immune cells.2
Biofilms can be part of the reason that some wounds may be difficult to heal, and persistent infections keep recurring.1 However, biofilms aren’t always undesirable, and can also house healthy bacteria in our digestive system and on our skin.3

Where are biofilms found?
A biofilm colony secretes materials that provide a structured matrix, similar to cement, that adheres to surfaces such as the lining of the gastrointestinal tract (GIT), urinary tract, respiratory system, heart, mouth (including the teeth), sex organs, eyes, the middle ear and skin.1 Biofilms can also form on medical materials such as catheters, joint replacements, heart valves and they commonly occur in hospitals.1

Common biofilms
A good example of a commonly understood biofilm is the accumulation of plaque (or biofilm) on the teeth. Treating and breaking down plaque can sometimes be challenging; the infection ‘hides’ in the plaque well away from antiseptic treatments and the immune system, sometimes causing gingivitis (inflammation of the gums).1
Another commonly known biofilm is sinusitis (sinus infection). The European Archives of Oto-Rhino-Laryngology published an observational study that showed that 59% of people suffering with a sinus infection had a sinus bacterial biofilm.4 Ear infections, often found in children, have been found to be associated with the presence of middle ear biofilms.1

Biofilms are good at ‘hiding’ microbes
Up to 80% of infections in the body affecting the body systems mentioned above are associated with biofilm formation.5 These biofilms can make it challenging for antimicrobial treatments to penetrate the biofilm.5 A microbial biofilm is continuously changing, stimulating inflammation, and acting as an obstacle for the action of the immune system.1 These types of persistent infections may be correlated to a range of health complaints including middle ear infections, urinary tract infections (UTIs), GIT infections, fungal overgrowth and more.1,6

Biofilm communication
The life cycle of the biofilm includes the microbes communicating via a process called ‘quorum sensing’; where the microbes send messages to each other to start the formation of the matrix (cement) of the biofilm.7 The microbes then communicate with each other as to their total number, and when they distinguish that there is a large colony, they start working as a community.7 Once the biofilm has been formed, channels are developed to allow nutrients in to enhance the development of the colony.7

So what natural compounds can help break down biofilms?
There are a number of natural compounds that may help to breakdown microbial biofilms. Some can preferentially target overgrowth of ‘bad’ microbes in biofilms, while enhancing ‘good’ bacterial biofilms3, such as:

  • Garlic has been found to be effective against fungal biofilms9
  • Oregano9
  • Cinnamon10
  • Curcumin11
  • N-acetylcysteine (NAC)12
  • Cranberry can be used to treat UTI-associated biofilms13
  • Ginger14

Speak to your healthcare practitioner for more information about supplementation. Make sure to always read the label and use only as directed. If symptoms persist, see your healthcare practitioner.

To find a practitioner in your area, visit our Find-A-Practitioner page.

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13. Reid G, Hsiehl J, Potter P, et al. Cranberry juice consumption may reduce biofilms on uroepithelial cells: pilot study in spinal cord injured patients. Spinal Cord 2001;39(1):26-30.
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