Dopaminergic disturbances
Date
30 Aug 2024
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Table of Contents
Dopamine is a pleiotropic neurotransmitter with essential roles in motivation, reward, movement, cognition, and the modulation of prolactin. Often incorrectly referred to as 'the pleasure molecule'; dopamine is best associated with the ‘want’ to do something, rather than the ‘liking’ or pleasure associated with doing something.1,2
Key highlights
- Dopamine is crucial for motivation, reward, movement, and cognition, but is incorrectly labeled as 'the pleasure molecule'.
- Disruptions in dopamine can lead to severe health issues, including akinesia and death by starvation in animals.
- Dopamine dysfunction is associated with addictions, depression, bipolar disorder, schizophrenia, ADHD, Alzheimer's, Parkinson's, and restless legs syndrome.
- Factors affecting dopamine activity include genetics, ageing, diet, medications, drugs, nutritional deficiencies, stress, inflammation, sleep, hormones, and gut health.
- Effective management includes addressing stress, diet, nutrition, sleep, inflammation, hormones, physical activity, and using supportive supplements and herbs.