Latest infographic: Intestinal permeability (IP): Breaking the vicious cycle
Date
05 Jan 2026
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Long-term goals to manage intestinal permeability focus on restoring gut barrier integrity, reducing immune activation, and supporting epithelial repair to limit antigen translocation and chronic inflammation.
Long-term goals to manage intestinal permeability focus on restoring gut barrier integrity, reducing immune activation, and supporting epithelial repair to limit antigen translocation and chronic inflammation. Conventional management of conditions associated with increased intestinal permeability often centres on symptom suppression using pharmaceuticals such as anti-inflammatory agents, acid suppression, or immunomodulatory therapies. While these may offer short-term relief, they do not address the underlying drivers of barrier dysfunction and may further compromise gut integrity over time.
Fortunately, targeted nutritional and herbal interventions have demonstrated clinically meaningful benefits in supporting intestinal barrier function. Evidence shows these approaches can be used long term to reduce inflammation, enhance tight junction integrity, support mucosal immunity, and improve microbial balance without the adverse effects associated with many pharmaceutical options.
This infographic examines the pathophysiology of increased intestinal permeability and highlights key therapeutic interventions, including Chios mastic gum, curcumin (Theracurmin®), glutamine, licorice root (GutGard®) and glutathione. These agents act via complementary mechanisms to support tight junction proteins, reduce oxidative stress, modulate immune responses, and restore gut barrier resilience in both gastrointestinal and systemic inflammatory conditions.
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