Latest article: Lutein: Brain, eyes, and sleep health
Date
02 Jun 2025
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Carotenoids are compounds synthesised by plants, algae, and bacteria. Hundreds of carotenoids exist in nature, but only about 50 of them are found regularly in the human diet, of which, only approximately 10 carotenoids can be detected in significant quantities in the human plasma.1 Lutein, and its isomer, zeaxanthin, are two carotenoids that are attracting significant attention for their potential health-enhancing effects.
Humans cannot synthesise lutein, so it must be obtained through the diet.2 High dietary sources of lutein include fruits and vegetables such as kale, spinach, broccoli, corn, and green peas. Lutein can also be obtained from egg yolks, which, due to its high-fat content, is a more bioavailable source.3,4 Although the primary purpose of this article is to provide an overview of lutein, it is commonly investigated with the carotenoid, zeaxanthin. This is because they have a similar molecular structure and are often found in the same foods, although the lutein content is typically 5 to 7 times greater than that of zeaxanthin.5,6
Key highlights
- Lutein supports early brain and eye development, being the most abundant carotenoid in infant brain tissue, cord blood, and breast milk.
- Lutein promotes visual health by accumulating in the macula, reducing risk of age-related macular degeneration (AMD) and cataracts, and protecting against blue light damage.
- Lutein enhances cognitive function across the lifespan, with higher levels linked to improved memory, brain efficiency, and reduced risk of cognitive decline.
- Lutein may improve sleep quality, likely due to its blue- light filtering effects and association with longer, more restful sleep.
- Mechanisms of action include antioxidant, anti- inflammatory, and neuroprotective, supporting synaptic health and stress resilience.
- Supplementation can be useful for individuals with poor diet, screen overuse, or cognitive and visual concerns. Dosage ranges 2-20 mg/day.
- Clinical assessment can include dietary evaluation and macular pigment optical density (MPOD) testing, with benefits typically observed after at least 3 months of supplementation.